Apply for CRI Clinical Innovator Program

Donor Name: Cancer Research Institute

Reference URL:https://www.cancerresearch.org/clinical-innovator

The Cancer Research Institute is inviting academic researchers to apply for the CRI Clinical Innovator program, which funds investigator-initiated immunotherapy clinical trials aimed at advancing novel cancer treatments and deepening understanding of immune mechanisms in oncology.

The CRI Clinical Innovator program was established to support pioneering clinical trials in immunotherapy, aiming to transform patient care and address areas of high unmet need in cancer treatment. By empowering clinician-scientists to lead investigator-initiated studies, the program seeks to generate critical mechanistic insights and advance the field of cancer immunotherapy.

This grant funds innovative phase I/II or phase II clinical studies that emphasize novel immunotherapy approaches, mechanistic investigations into clinical response, and the discovery or validation of predictive biomarkers. Strategic guidance on trial design may be provided, and data sharing is encouraged through platforms such as the CRI iATLAS. In partnership with the Chordoma Foundation, proposals focused on chordoma research are also invited and may be co-funded, with access to specialized chordoma models and tumor samples.

Grants of up to $1,000,000 per trial are available, with funding eligible for investigator salary, patient costs, supplies, correlative assays, and data analyses. Indirect costs of up to 10% are provided in addition to the awarded funds, and payments are structured in milestones to ensure progress and completion.

Eligible applicants must be the Principal Investigator of the proposed study, with no citizenship restrictions. Research may be conducted at medical schools or research centers in the United States or abroad, but for-profit institutions are not eligible for support.

For more information, visit Cancer Research Institute.

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